(AP) — San Francisco's standout inside linebacker Patrick Willis was inactive Sunday when the 49ers met the Arizona Cardinals, only the second game he has missed in his career.
He sat out the regular season finale in 2010 with a broken hand.
Willis, who did some stretching before Sunday's game, did not practice all last week because of a right hamstring injury. He was replaced in the lineup by Larry Grant.
49ers wide receiver Braylon Edwards was active after missing last week's NFC West-clinching victory over St. Louis with a sore right knee.
Arizona had three wide receivers inactive as coach Ken Whisenhunt chose to dress all four of his tight ends.